Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680884 | 0.91 | ABCB11 (0.81) | ABCB11MAPTLMNACCR2ALDH1A1 | |
| SCHEMBL7691746 | 0.90 | ABCB11 (1.00) | ABCB11MAPTLMNACCR2 | |
| SCHEMBL7679796 | 0.88 | MAPT (0.80) | ABCB11MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL7701288 | 0.79 | MAPT (0.76) | ABCB11MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL7679941 | 0.77 | ABCB11 (0.78) | ABCB11CCR2 | |
| SCHEMBL7682546 | 0.76 | ABCB11 (0.76) | ABCB11MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6598061 | 0.76 | CCR2 (0.79) | ABCB11CCR2 | |
| SCHEMBL7682571 | 0.75 | ABCB11 (0.73) | ABCB11CCR2 | |
| SCHEMBL7680085 | 0.74 | ABCB11 (0.73) | ABCB11CCR2 | |
| SCHEMBL6597871 | 0.74 | CCR2 (0.80) | ABCB11CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |