Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 13/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.50 |
| ▸ | NPC1L1 | Q9UHC9 | 4/20 | 0.49 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7701385 | 0.99 | OPRL1 (0.60) | OPRL1OPRM1OPRD1OPRK1NPC1L1 | |
| SCHEMBL8908168 | 0.81 | NPC1L1 (0.56) | OPRL1OPRM1OPRD1OPRK1NPC1L1 | |
| SCHEMBL7709408 | 0.81 | OPRL1 (0.61) | OPRL1OPRM1OPRD1OPRK1NPC1L1 | |
| Hydrochloric Acid SCHEMBL7706309 | 0.81 | OPRL1 (0.65) | OPRL1OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL7709456 | 0.80 | OPRL1 (0.64) | OPRL1OPRM1OPRD1OPRK1BDKRB2 | |
| Hydrochloric Acid SCHEMBL7705553 | 0.80 | OPRL1 (0.60) | OPRL1OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL7706313 | 0.80 | OPRL1 (0.60) | OPRL1OPRM1OPRD1OPRK1NPC1L1 | |
| SCHEMBL318863 | 0.80 | OPRL1 (0.49) | OPRL1OPRM1OPRD1OPRK1NPC1L1 | |
| Hydrochloric Acid SCHEMBL7709420 | 0.80 | OPRL1 (0.63) | OPRL1OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL7709434 | 0.80 | OPRL1 (0.63) | OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921125-B1 | 1,3,8-Triazaspiro[4,5]decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 2002-01-30 | — | — | EP | disclosed |
| EP-0921125-A1 | 1,3,8-Triaza-spiro 4,5 decan-4-on derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |