SCHEMBL7701583

SCHEMBL7701583

COC(Cc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1)OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 2/20 0.54
CA2 P00918 3/20 0.52
CA1 P00915 2/20 0.52
ALDH1A1 P00352 8/20 0.52
TSHR P16473 3/20 0.52
LMNA P02545 2/20 0.52
GAA P10253 2/20 0.52
MAPK1 P28482 3/20 0.50
MEN1 O00255 2/20 0.50
CYP1A2 P05177 2/20 0.50
CYP3A4 P08684 2/20 0.50
BLM P54132 2/20 0.50
KMT2A Q03164 2/20 0.50
ATM Q13315 2/20 0.50
HIF1A Q16665 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
ALOX15 P16050 2/20 0.50
GMNN O75496 1/20 0.50
GABBR2 O75899 1/20 0.50
TP53 P04637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL39082 0.80 HMGCR (0.57) HMGCRCA2CA1ALDH1A1TSHR
SCHEMBL11776509 0.78 ALDH1A1 (0.53) HMGCRCA2CA1ALDH1A1TSHR
Ammonia Solution, Strong SCHEMBL11660895 0.78 HMGCR (0.55) HMGCRCA2CA1ALDH1A1TSHR
SCHEMBL490407 0.78 HMGCR (0.51) HMGCRCA2CA1ALDH1A1TSHR
SCHEMBL8125562 0.77 ALDH1A1 (0.55) HMGCRCA2CA1ALDH1A1TSHR
SCHEMBL11587457 0.77 HMGCR (0.54) HMGCRCA2CA1ALDH1A1TSHR
SCHEMBL11268336 0.77 ALDH1A1 (0.55) HMGCRCA2CA1ALDH1A1TSHR
SCHEMBL9722445 0.77 HMGCR (0.54) HMGCRCA2CA1ALDH1A1TSHR
SCHEMBL4145721 0.76 HMGCR (0.54) HMGCRCA2CA1ALDH1A1TSHR
SCHEMBL7084466 0.76 HMGCR (0.74) HMGCRCA2CA1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4708966-A SUBSTITUTED DI-TERT-BUTYL PHENOL DERIVATIVES THE PROCTER & GAMBLE COMPANY (US) 1987-11-24 US claimed
US-6420428-B1 TREATING HEPATITIS C AND HEPATIC FIBROSIS USING 2,6-DI-TERT-BUTYLPHENOL DERIVATIVES; EFFECTIVE IN SUBJECTS WITH INTERFERON INSUSCEPTIBILITY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2002-07-16 US disclosed
US-6369097-B1 Treatment and prevention of hepatic disorders THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2002-04-09 US disclosed
US-6348493-B1 TREATMENT OF HEPATITIS C BY ADMINISTERING 2,6-DI-TER-BUTYLPHENOL THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2002-02-19 US disclosed
US-6218437-B1 ADMINISTERING A THERAPEUTIC AMOUNT OF DI-TERT-BUTYLPHENOL DERIVATIVE TO SUBJECT UNDER CONDITIONS SUCH THAT SAID SYMPTOMS ARE DIMINISHED THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2001-04-17 US disclosed
WO-2001021166-A1 TREATMENT AND PREVENTION OF HEPATIC DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2001-03-29 WO disclosed
EP-0251408-B1 NOVEL ANTI-INFLAMMATORY AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR REDUCING INFLAMMATION THE PROCTER & GAMBLE COMPANY (US) 1991-04-17 EP disclosed
US-4708966-A SUBSTITUTED DI-TERT-BUTYL PHENOL DERIVATIVES THE PROCTER & GAMBLE COMPANY (US) 1987-11-24 US disclosed