Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11947177 | 0.93 | MAPK1 (0.48) | TP53MEN1KMT2ALMNAMAPK1 | |
| SCHEMBL1538402 | 0.91 | LMNA (0.58) | TP53MEN1KMT2AATMLMNA | |
| SCHEMBL30006499 | 0.91 | LMNA (0.58) | TP53MEN1KMT2AATMLMNA | |
| SCHEMBL6863006 | 0.80 | TP53 (0.50) | TP53MEN1KMT2AATMLMNA | |
| SCHEMBL5657981 | 0.80 | LMNA (0.53) | TP53MEN1KMT2ALMNAMAPT | |
| SCHEMBL14094469 | 0.79 | ATM (0.39) | MEN1KMT2AATMMAPK1ALDH1A1 | |
| SCHEMBL880275 | 0.79 | TP53 (0.57) | TP53MEN1KMT2AATMLMNA | |
| SCHEMBL880444 | 0.76 | TP53 (0.59) | TP53MEN1KMT2ALMNAMAPK1 | |
| SCHEMBL4371172 | 0.74 | TP53 (0.55) | TP53MEN1KMT2AATMLMNA | |
| SCHEMBL12559670 | 0.74 | TDP1 (0.57) | TP53MEN1KMT2AATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019395-B1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-30 | — | — | EP | disclosed |
| EP-1106610-A1 | Farnesyl transferase inhibiting 2-quinolone derivatives | Janssen Pharmaceutica N.V. (BE) | 2001-06-13 | — | — | EP | disclosed |
| EP-1019395-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-07-19 | — | — | EP | disclosed |
| US-5968952-A | ANTITUMOR AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-10-19 | — | — | US | disclosed |
| WO-1997016443-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-09 | — | — | WO | disclosed |