Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1538402 | 1.00 | LMNA (0.58) | LMNATP53KMT2AMEN1ATM | |
| SCHEMBL7701639 | 0.91 | TP53 (0.51) | LMNATP53KMT2AMEN1ATM | |
| SCHEMBL5657981 | 0.89 | LMNA (0.53) | LMNATP53KMT2AMEN1NPC1 | |
| SCHEMBL11947177 | 0.83 | MAPK1 (0.48) | LMNATP53KMT2AMEN1NPC1 | |
| SCHEMBL13177884 | 0.83 | LMNA (0.47) | LMNATP53GAAHTTNPSR1 | |
| SCHEMBL4371172 | 0.81 | TP53 (0.55) | LMNATP53KMT2AMEN1ATM | |
| SCHEMBL880264 | 0.79 | LMNA (0.67) | LMNATP53KMT2AMEN1NPC1 | |
| SCHEMBL30005837 | 0.79 | LMNA (0.67) | LMNATP53KMT2AMEN1NPC1 | |
| SCHEMBL880483 | 0.78 | LMNA (0.62) | LMNATP53KMT2AMEN1ATM | |
| SCHEMBL5555500 | 0.76 | MEN1 (0.47) | TP53KMT2AMEN1ATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072490-B | High-efficiency synthesis method of tipifarnib quinolinone intermediate | 中国海洋大学 | 2022-08-16 | — | — | CN | claimed |
| CN-113072490-B | High-efficiency synthesis method of tipifarnib quinolinone intermediate | 中国海洋大学 | 2022-08-16 | — | — | CN | disclosed |
| CN-113072490-B | High-efficiency synthesis method of tipifarnib quinolinone intermediate | 中国海洋大学 | 2022-08-16 | — | — | CN | disclosed |