Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 13/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sotalol SCHEMBL16407 | 0.80 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Sotalol SCHEMBL6508618 | 0.80 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Dexsotalol SCHEMBL203209 | 0.80 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Sotalol SCHEMBL29761416 | 0.80 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Dexsotalol SCHEMBL5661932 | 0.79 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Sotalol SCHEMBL20575697 | 0.79 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Sotalol SCHEMBL118761 | 0.79 | ADRB3 (1.00) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Sotalol SCHEMBL3127442 | 0.78 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Sotalol SCHEMBL1649808 | 0.78 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNAKDM4E | |
| Sotalol SCHEMBL3287528 | 0.78 | ADRB3 (0.94) | ADRB3ADRB2ADRB1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037871-B1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET (HU) | 2002-07-03 | — | — | EP | disclosed |
| US-6265445-B1 | CARDIOVASCULAR DISORDERS | GYOGYSZERKUTATO INTEZET KFT (HU) | 2001-07-24 | — | — | US | disclosed |
| US-4044150-A | BETA-ADRENERGIC BLOCKING AGENT, HYPOTENSIVE | MEAD JOHNSON & COMPANY (US) | 1977-08-23 | — | — | US | disclosed |
| US-4044150-A | BETA-ADRENERGIC BLOCKING AGENT, HYPOTENSIVE | MEAD JOHNSON & COMPANY (US) | 1977-08-23 | — | — | US | disclosed |