Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.51 |
| ▸ | PPARA | Q07869 | 5/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR5A | P47898 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7698166 | 0.99 | PPARG (0.50) | PPARGPPARALTA4HNPC1RAB9A | |
| SCHEMBL8725506 | 0.95 | LTA4H (0.56) | PPARGPPARALTA4HNPC1RAB9A | |
| SCHEMBL7697676 | 0.82 | CYP2D6 (0.67) | PPARGPPARAMEN1KMT2ACYP2D6 | |
| SCHEMBL11835059 | 0.78 | PPARG (0.61) | PPARGPPARAS1PR1S1PR3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11843021 | 0.78 | PPARG (0.60) | PPARGPPARAS1PR1S1PR3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11832653 | 0.76 | PPARG (0.61) | PPARGPPARAS1PR1S1PR3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11842023 | 0.75 | PPARG (0.60) | PPARGPPARAS1PR1S1PR3SIGMAR1 | |
| SCHEMBL11837347 | 0.74 | PPARG (0.58) | PPARGPPARALTA4HS1PR1S1PR3 | |
| SCHEMBL8010714 | 0.74 | SIGMAR1 (0.72) | SIGMAR1DRD2MEN1KMT2AHTR7 | |
| SCHEMBL28057913 | 0.74 | SIGMAR1 (0.56) | PPARGPPARASIGMAR1DRD2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885004-B1 | USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS | HOFFMANN LA ROCHE (CH) | 2002-05-02 | — | — | EP | claimed |