Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702331 | 0.79 | ALDH1A1 (0.45) | TSHRALDH1A1MAPK1USP2SMN1; SMN2 | |
| SCHEMBL3997775 | 0.65 | ALDH1A1 (0.64) | TSHRALDH1A1MAPK1USP2SMN1; SMN2 | |
| SCHEMBL3996272 | 0.65 | TSHR (0.59) | TSHRALDH1A1MAPK1USP2SMN1; SMN2 | |
| SCHEMBL3996318 | 0.64 | ALDH1A1 (0.55) | TSHRALDH1A1MAPK1USP2SMN1; SMN2 | |
| SCHEMBL7697790 | 0.63 | ALDH1A1 (0.35) | TSHRALDH1A1MAPK1USP2SMN1; SMN2 | |
| SCHEMBL14697013 | 0.63 | HSD17B10 (0.56) | ALDH1A1HSD17B10LMNAGAA | |
| SCHEMBL11174072 | 0.63 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2TP53KMT2ALMNA | |
| SCHEMBL16891569 | 0.63 | NPC1 (0.52) | TSHRALDH1A1USP2SMN1; SMN2KMT2A | |
| SCHEMBL15936325 | 0.63 | ALDH1A1 (0.50) | TSHRALDH1A1HSD17B10KMT2ALMNA | |
| SCHEMBL1911955 | 0.62 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6346527-B1 | 1-BENZOXEPIN DERIVATIVES USED IN THE PREVENTION OF SODIUM AND HYDROGEN ION EXCHANGE; CARDIOVASCULAR, KIDNEY AND BRAIN DISORDER TREATMENT; ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-12 | — | — | US | disclosed |