Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702409 | 0.83 | FFAR1 (0.46) | MAPTGAAHDAC6HDAC2HDAC8 | |
| SCHEMBL3360788 | 0.79 | KEAP1 (0.61) | HDAC6HDAC2HDAC8HDAC1 | |
| SCHEMBL622181 | 0.78 | HDAC2 (0.68) | MAPTGAAHDAC6HDAC2HDAC8 | |
| SCHEMBL5748661 | 0.77 | SIRT2 (0.51) | MAPTHDAC6HDAC1HTTPTPN1 | |
| SCHEMBL16623155 | 0.73 | ERCC1 (0.60) | GAAHDAC2HDAC8PTPN1ALDH1A1 | |
| SCHEMBL10575824 | 0.72 | SMN1; SMN2 (0.63) | MAPTHDAC6HDAC2HDAC8HDAC1 | |
| SCHEMBL8005008 | 0.70 | TDP1 (0.52) | MAPTGAAALDH1A1 | |
| SCHEMBL28752888 | 0.70 | MEN1 (0.35) | — | |
| SCHEMBL9579600 | 0.70 | CYP1A2 (0.61) | MAPT | |
| SCHEMBL22276673 | 0.70 | TDP1 (0.56) | HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183251-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | Almirall Prodesfarma, S.A. (ES) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000075130-A1 | INDOLYLPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALLERGIC AGENTS | ALMIRALL PRODESFARMA, S.A. (ES) | 2000-12-14 | — | — | WO | disclosed |