Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | CDC25C | P30307 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7705362 | 0.99 | KCNH2 (0.67) | KCNH2SIGMAR1CDC25CMAPTMEN1 | |
| SCHEMBL7705321 | 0.86 | KCNH2 (0.70) | KCNH2SIGMAR1CDC25CMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7703032 | 0.85 | KCNH2 (0.69) | KCNH2SIGMAR1CDC25CMEN1KMT2A | |
| SCHEMBL10721556 | 0.83 | KCNH2 (0.62) | KCNH2SIGMAR1CDC25CMAPTMEN1 | |
| SCHEMBL3929250 | 0.82 | KCNH2 (1.00) | KCNH2SIGMAR1CDC25C | |
| SCHEMBL7698337 | 0.81 | KCNH2 (0.51) | KCNH2SIGMAR1ALDH1A1 | |
| SCHEMBL8217379 | 0.80 | KCNH2 (0.49) | KCNH2SIGMAR1CDC25CMEN1KMT2A | |
| SCHEMBL7699391 | 0.80 | KCNH2 (0.46) | KCNH2SIGMAR1CDC25CMAPTMEN1 | |
| SCHEMBL9628028 | 0.80 | KCNH2 (0.74) | KCNH2SIGMAR1CDC25CMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7697786 | 0.79 | KCNH2 (0.46) | KCNH2SIGMAR1CDC25CMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037871-B1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET (HU) | 2002-07-03 | — | — | EP | disclosed |
| US-6265445-B1 | CARDIOVASCULAR DISORDERS | GYOGYSZERKUTATO INTEZET KFT (HU) | 2001-07-24 | — | — | US | disclosed |
| EP-1037871-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029655-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | Gyógyszerkutató Intézet Kft. (HU) | 1999-06-17 | — | — | WO | disclosed |