Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.70 |
| ▸ | CDC25C | P30307 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.52 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13897015 | 0.93 | KCNH2 (0.72) | KCNH2SIGMAR1CDC25CTSHRMEN1 | |
| SCHEMBL9628754 | 0.92 | KCNH2 (0.65) | KCNH2SIGMAR1CDC25CTSHRPYCR1 | |
| SCHEMBL3143117 | 0.91 | KCNH2 (0.64) | KCNH2SIGMAR1CDC25CTSHRPYCR1 | |
| Hydrochloric Acid SCHEMBL9628308 | 0.90 | SIGMAR1 (0.64) | KCNH2SIGMAR1CDC25CTSHRPYCR1 | |
| SCHEMBL777298 | 0.89 | KCNH2 (0.60) | KCNH2SIGMAR1CDC25CTSHRPYCR1 | |
| SCHEMBL3929250 | 0.86 | KCNH2 (1.00) | KCNH2SIGMAR1CDC25C | |
| SCHEMBL9628032 | 0.86 | KCNH2 (0.63) | KCNH2SIGMAR1CDC25CTSHRPYCR1 | |
| SCHEMBL3149347 | 0.85 | ALDH1A1 (0.63) | KCNH2SIGMAR1CDC25CPYCR1MEN1 | |
| SCHEMBL7596877 | 0.85 | ALDH1A1 (0.63) | KCNH2SIGMAR1CDC25CPYCR1MEN1 | |
| SCHEMBL13354551 | 0.85 | KCNH2 (0.58) | KCNH2SIGMAR1CDC25CTSHRPYCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | disclosed |