Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 12/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9099675 | 0.88 | TRPA1 (0.61) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| Dibenzo[B,F][1,4]Oxazepine SCHEMBL123289 | 0.79 | TRPA1 (1.00) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| Dibenzo[B,F][1,4]Oxazepine SCHEMBL30601896 | 0.77 | TRPA1 (0.96) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL6852823 | 0.76 | CA12 (0.47) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL8105009 | 0.74 | CA12 (0.42) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL17849590 | 0.73 | TRPA1 (0.33) | TRPA1CA12CA1CA2CA9 | |
| SCHEMBL15613266 | 0.72 | LMNA (0.51) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL5033603 | 0.70 | — | — | |
| SCHEMBL9274057 | 0.69 | TRPA1 (0.70) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL11541615 | 0.69 | CA12 (0.38) | TRPA1LMNAMAPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892804-B1 | ISOXAZOLIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-08-28 | — | — | EP | disclosed |
| US-6156747-A | Isoxazolidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-12-05 | — | — | US | disclosed |
| EP-0892804-A1 | ISOXAZOLIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997039001-A1 | ISOXAZOLIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-10-23 | — | — | WO | disclosed |
| US-5547951-A | ENZYME INHIBITORS; AIDS | BOEHRINGER INGELHEIM PHARAMCEUTICALS, INC. (US) | 1996-08-20 | — | — | US | disclosed |
| US-5547951-A | ENZYME INHIBITORS; AIDS | BOEHRINGER INGELHEIM PHARAMCEUTICALS, INC. (US) | 1996-08-20 | — | — | US | disclosed |
| US-5547951-A | ENZYME INHIBITORS; AIDS | BOEHRINGER INGELHEIM PHARAMCEUTICALS, INC. (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0417534-A1 | Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and thiones and their use in the prevention or treatment of AIDS | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0417534-A1 | Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and thiones and their use in the prevention or treatment of AIDS | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0417534-A1 | Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and thiones and their use in the prevention or treatment of AIDS | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1991-03-20 | — | — | EP | disclosed |