Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.49 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167099 | 1.00 | PI4KB (0.53) | PI4KBHPGDADRA1AADRA1BBCL2L1 | |
| SCHEMBL26536805 | 0.85 | HTT (0.49) | PI4KBHPGDADRA1AADRA1BSMN1; SMN2 | |
| SCHEMBL27917833 | 0.81 | TGFBR1 (0.54) | ADRA1AADRA1BSMN1; SMN2ALDH1A1HTR7 | |
| SCHEMBL1587204 | 0.79 | MAPT (0.62) | PI4KBBCL2L1MCL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11705019 | 0.78 | NPY5R (0.62) | HPGDBCL2L1MCL1SMN1; SMN2GBA1 | |
| SCHEMBL7702998 | 0.78 | MAPT (0.59) | HPGDBCL2L1MCL1SMN1; SMN2GBA1 | |
| SCHEMBL5163011 | 0.77 | TGFBR1 (0.56) | ALDH1A1 | |
| SCHEMBL29183291 | 0.74 | ALDH1A1 (0.64) | HPGDSMN1; SMN2ALDH1A1CNR2CNR1 | |
| SCHEMBL28593071 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL7886816 | 0.74 | GBA1 (0.83) | BCL2L1MCL1SMN1; SMN2GBA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-06-22 | — | — | US | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135773-A1 | Trisubstituted nitrogen modulators of tyrosine phosphatases | PTPA, PTPN1, PTPRS | PI4KB 227/4885HPGD 2983/4885ADRA1A 4657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.