Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP51A1 | Q16850 | 5/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.39 |
| ▸ | FNTA | P49354 | 4/20 | 0.39 |
| ▸ | FNTB | P49356 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703291 | 1.00 | AGTR2 (0.45) | AGTR2CYP3A4CYP2C19CYP51A1CYP26A1 | |
| SCHEMBL8206537 | 0.93 | FNTA (0.46) | AGTR2CYP3A4CYP2C19FNTAFNTB | |
| SCHEMBL7703276 | 0.93 | FNTA (0.46) | AGTR2CYP3A4CYP2C19FNTAFNTB | |
| SCHEMBL7706109 | 0.93 | FNTA (0.46) | AGTR2CYP3A4CYP2C19FNTAFNTB | |
| SCHEMBL7703271 | 0.93 | FNTA (0.46) | AGTR2CYP3A4CYP2C19FNTAFNTB | |
| SCHEMBL7706112 | 0.93 | FNTA (0.46) | AGTR2CYP3A4CYP2C19FNTAFNTB | |
| SCHEMBL7703354 | 0.90 | AGTR2 (0.48) | AGTR2CYP3A4CYP2C19CYP51A1CYP26A1 | |
| SCHEMBL7703357 | 0.90 | AGTR2 (0.48) | AGTR2CYP3A4CYP2C19CYP51A1CYP26A1 | |
| SCHEMBL7703342 | 0.88 | AGTR2 (0.45) | AGTR2CYP3A4CYP2C19CYP51A1CYP26A1 | |
| SCHEMBL7703345 | 0.88 | AGTR2 (0.45) | AGTR2CYP3A4CYP2C19CYP51A1CYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414145-B1 | TREATING CANCER AND NEUROFIBROMATOSIS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | disclosed |