Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 2/20 | 0.68 |
| ▸ | CA12 | O43570 | 3/20 | 0.57 |
| ▸ | CA1 | P00915 | 3/20 | 0.57 |
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | CA7 | P43166 | 3/20 | 0.57 |
| ▸ | CA9 | Q16790 | 3/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.57 |
| ▸ | HNF4A | P41235 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206002 | 0.89 | PTPN11 (0.66) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL7914505 | 0.88 | PTPN11 (0.65) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL23895474 | 0.82 | PTPN11 (1.00) | PTPN11 | |
| SCHEMBL8058019 | 0.81 | PTPN11 (0.58) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL14252074 | 0.81 | PTPN11 (0.51) | PTPN11HNF4ALMNAEGFRGAA | |
| SCHEMBL546514 | 0.80 | CA12 (0.61) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL7711875 | 0.80 | CA12 (0.61) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL7894709 | 0.80 | PTPN11 (0.56) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL15603819 | 0.80 | CA12 (0.65) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL29820043 | 0.80 | CA12 (0.65) | PTPN11CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417178-B1 | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits | UNIVERSITY OF PITTSBURGH | 2002-07-09 | — | — | US | disclosed |
| US-6168776-B1 | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition | UNIVERSITY OF PITTSBURGH | 2001-01-02 | — | — | US | disclosed |
| US-6133259-A | DIAGNOSIS OF ALZHEIMER'S DISEASE | UNIVERSITY OF PITTSBURGH (US) | 2000-10-17 | — | — | US | disclosed |