Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.54 |
| ▸ | CA2 | P00918 | 3/20 | 0.54 |
| ▸ | CA7 | P43166 | 3/20 | 0.54 |
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HNF4A | P41235 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872253 | 0.88 | CA12 (0.54) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL21052511 | 0.88 | PTPN11 (0.44) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL28568675 | 0.85 | GABRA1 (0.44) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL1785873 | 0.84 | MEN1 (0.45) | PTPN11TSHRLMNAGAAHPGD | |
| SCHEMBL8206002 | 0.83 | PTPN11 (0.66) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL9081505 | 0.82 | PTPN11 (0.39) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL8180164 | 0.82 | GABRA1 (0.41) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL7703308 | 0.81 | PTPN11 (0.68) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL7728547 | 0.81 | NQO2 (0.39) | PTPN11CA12CA1CA2CA7 | |
| SCHEMBL2335866 | 0.81 | ABL1 (0.42) | PTPN11CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0613468-B1 | Substituted salicylic acids for the treatment of autoimmune diseases | PHARMACIA & UPJOHN AB (SE) | 2000-07-12 | — | — | EP | disclosed |
| CN-1042631-C | Novel substituted salicylic acids | KABI PHARMACIA AB (SE) | 1999-03-24 | — | — | CN | disclosed |
| US-5556855-A | TREATMENT OF AUTOIMMUNE DISEASES | PHARMACIA AB (SE) | 1996-09-17 | — | — | US | disclosed |
| US-5403930-A | Chemical intermediate for drugs used in autoimmune diseases | PHARMACIA AB (SE) | 1995-04-04 | — | — | US | disclosed |
| EP-0613468-A1 | NOVEL SUBSTITUTED SALICYCLIC ACIDS | Pharmacia & Upjohn Aktiebolag (SE) | 1994-09-07 | — | — | EP | disclosed |
| CN-1088918-A | The salicylic acid compounds of new replacement | KABI PHARMACIA AB (SE) | 1994-07-06 | — | — | CN | disclosed |
| US-5302718-A | Used for treating autoimmune diseases | KABI PHARMACIA AB (SE) | 1994-04-12 | — | — | US | disclosed |
| WO-1993010094-A1 | NOVEL SUBSTITUTED SALICYCLIC ACIDS | KABI PHARMACIA AB (SE) | 1993-05-27 | — | — | WO | disclosed |