Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.57 |
| ▸ | PRCP | P42785 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 8/20 | 0.44 |
| ▸ | HTR2C | P28335 | 8/20 | 0.44 |
| ▸ | HTR2B | P41595 | 5/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703317 | 1.00 | TRPM5 (0.57) | TRPM5PRCPALOX12GAAMAPT | |
| SCHEMBL7703323 | 1.00 | TRPM5 (0.57) | TRPM5PRCPALOX12GAAMAPT | |
| SCHEMBL7700195 | 0.83 | PRCP (0.48) | TRPM5PRCPGAAMAPTKDM1A | |
| SCHEMBL7700199 | 0.83 | PRCP (0.48) | TRPM5PRCPGAAMAPTKDM1A | |
| SCHEMBL5023257 | 0.82 | RECQL (0.59) | PRCPALOX12GAAMAPTHTR2A | |
| SCHEMBL7702387 | 0.82 | RECQL (0.59) | PRCPALOX12GAAMAPTHTR2A | |
| SCHEMBL7698338 | 0.82 | RECQL (0.59) | PRCPALOX12GAAMAPTHTR2A | |
| SCHEMBL7700080 | 0.80 | PRCP (0.57) | PRCPALOX12GAAMAPTTDP1 | |
| SCHEMBL7700079 | 0.80 | PRCP (0.57) | PRCPALOX12GAAMAPTTDP1 | |
| Hydrochloric Acid SCHEMBL2794166 | 0.79 | PRCP (0.56) | PRCPALOX12GAAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |