SCHEMBL7703476

SCHEMBL7703476

CCCCc1nc(SCC)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1

nearest known ligand 0.76

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.76
AGTR2 P50052 2/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8858876 0.91 AGTR1 (0.76) AGTR1AGTR2
SCHEMBL8858880 0.90 AGTR2 (0.61) AGTR1AGTR2
SCHEMBL7706792 0.90 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL8823590 0.88 AGTR1 (0.58) AGTR1AGTR2
SCHEMBL89 0.86 AGTR1 (1.00) AGTR1AGTR2
SCHEMBL29486822 0.86 AGTR1 (1.00) AGTR1AGTR2
SCHEMBL9339135 0.86 AGTR1 (0.81) AGTR1AGTR2
SCHEMBL7706072 0.86 AGTR1 (0.57) AGTR1AGTR2
SCHEMBL7709126 0.86 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL9468476 0.85 AGTR1 (0.98) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0644188-B1 Process for the preparation of sulfur derivatives of imidazole and intermediates obtained AVENTIS PHARMA SA (FR) 2002-12-04 EP claimed
EP-0648763-B1 Process for the preparation of sulfur derivatives of imidazole and intermediates obtained AVENTIS PHARMA SA (FR) 2001-05-09 EP claimed
EP-0465368-B1 Sulfur derivatives of imidazole, process for their preparation, intermediates, their use as medicaments, and pharmaceutical compositions containing them HOECHST MARION ROUSSEL INC (FR) 1998-05-20 EP claimed
US-5599830-A ANGIOTENSIN INHIBITORS ROUSSEL UCLAF (FR) 1997-02-04 US claimed
US-5412101-A Angiotensin II inhibitor ROUSSEL-UCLAF (FR) 1995-05-02 US claimed
US-5599830-A ANGIOTENSIN INHIBITORS ROUSSEL UCLAF (FR) 1997-02-04 US disclosed
US-5412101-A Angiotensin II inhibitor ROUSSEL-UCLAF (FR) 1995-05-02 US disclosed