SCHEMBL7703486

SCHEMBL7703486

CCCCc1nc(Sc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1

nearest known ligand 0.74

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.66
AGTR2 P50052 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8858876 0.91 AGTR1 (0.76) AGTR1AGTR2
SCHEMBL7706063 0.90 AGTR1 (0.69) AGTR1AGTR2
SCHEMBL7706792 0.90 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL8823602 0.89 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL8823621 0.88 AGTR1 (0.65) AGTR1AGTR2
SCHEMBL7706142 0.87 AGTR1 (0.61) AGTR1AGTR2
SCHEMBL9873124 0.86 AGTR2 (0.62) AGTR1AGTR2
SCHEMBL8823513 0.86 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL708 0.85 AGTR1 (0.80) AGTR1AGTR2
SCHEMBL8823537 0.85 AGTR1 (0.66) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0644188-B1 Process for the preparation of sulfur derivatives of imidazole and intermediates obtained AVENTIS PHARMA SA (FR) 2002-12-04 EP claimed
EP-0648763-B1 Process for the preparation of sulfur derivatives of imidazole and intermediates obtained AVENTIS PHARMA SA (FR) 2001-05-09 EP claimed
EP-0465368-B1 Sulfur derivatives of imidazole, process for their preparation, intermediates, their use as medicaments, and pharmaceutical compositions containing them HOECHST MARION ROUSSEL INC (FR) 1998-05-20 EP claimed
US-5599830-A ANGIOTENSIN INHIBITORS ROUSSEL UCLAF (FR) 1997-02-04 US claimed
US-5412101-A Angiotensin II inhibitor ROUSSEL-UCLAF (FR) 1995-05-02 US claimed
JP-4230369-A None JP disclosed
JP-7215945-A None JP disclosed
US-5684028-A ANGIOTENSIN II INHIBITORS ROUSSEL UCLAF (FR) 1997-11-04 US disclosed
US-5599830-A ANGIOTENSIN INHIBITORS ROUSSEL UCLAF (FR) 1997-02-04 US disclosed
US-5527919-A Process for the preparation of 1-[(1,1'-biphenyl]-4-YL]-methyl-1H-imidazole-5-carboxylic acids ROUSSEL UCLAF (FR) 1996-06-18 US disclosed
JP-H07215945-A NOVEL PROCESS FOR PRODUCTION OF SULFATED DERIVATIVE OF IMIDAZOLE AND OBTAINED NOVEL INTERMEDIATE ROUSSEL UCLAF 1995-08-15 JP disclosed
US-5412101-A Angiotensin II inhibitor ROUSSEL-UCLAF (FR) 1995-05-02 US disclosed
JP-H04230369-A NEW SULFUR DERIVATIVE OF IMIDAZOL AND ITS PRODUCTION, OBTAINED NEW INTERMEDIATE, ITS USE AS DRUG, AND MEDICINAL COMPOSITION CONTAINING THE SAME ROUSSEL UCLAF 1992-08-19 JP disclosed