Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 5/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7706111 | 0.77 | SLC6A9 (0.43) | SLC6A9MTNR1AMTNR1BHPGDALDH1A1 | |
| Lithium Ion SCHEMBL7702608 | 0.74 | SLC6A9 (0.52) | SLC6A9MTNR1AMTNR1BTRPM8TACR1 | |
| Lithium Ion SCHEMBL7702844 | 0.73 | SLC6A9 (0.63) | SLC6A9SLC6A2SLC6A4MTNR1AMTNR1B | |
| Lithium Ion SCHEMBL7703444 | 0.72 | SLC6A9 (0.62) | SLC6A9SLC6A2SLC6A4MTNR1AMTNR1B | |
| Lithium Ion SCHEMBL7698448 | 0.72 | SLC6A9 (0.54) | SLC6A9MTNR1AMTNR1BTRPM8TACR1 | |
| Lithium Ion SCHEMBL7704198 | 0.71 | SLC6A9 (0.51) | SLC6A9MTNR1AMTNR1BHTR2CHTR2B | |
| Org-25935 SCHEMBL7703028 | 0.70 | SLC6A9 (0.85) | SLC6A9MTNR1AMTNR1B | |
| Lithium Ion SCHEMBL7702768 | 0.70 | SLC6A9 (0.60) | SLC6A9MTNR1AMTNR1BFFAR1TACR1 | |
| Lithium Ion SCHEMBL7706983 | 0.70 | SLC6A9 (0.71) | SLC6A9MTNR1AMTNR1B | |
| Org-25935 SCHEMBL7704305 | 0.70 | SLC6A9 (0.85) | SLC6A9MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100769-B1 | AMINOMETHYLCARBOXYLIC ACID DERIVATIVES | AKZO NOBEL NV (NL) | 2002-12-04 | — | — | EP | disclosed |
| US-6410592-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | AKZO NOBEL N.V. (NL) | 2002-06-25 | — | — | US | disclosed |