Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL73148 | 0.83 | MAPT (0.38) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL73387 | 0.80 | KDM4E (0.36) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL75224 | 0.79 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL72743 | 0.74 | MAOA (0.49) | MAPTTSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL2560611 | 0.71 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL20457804 | 0.71 | SMN1; SMN2 (0.30) | SMN1; SMN2 | |
| SCHEMBL74891 | 0.71 | PDE4D (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7650714 | 0.65 | NPC1 (0.42) | HSD17B10ALDH1A1CYP19A1LMNACYP1A2 | |
| SCHEMBL26771405 | 0.64 | SMN1; SMN2 (0.42) | MAPTTSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL25662814 | 0.63 | CCR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |