Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27890836 | 0.87 | FGFR4 (0.38) | NPC1CYP1A2CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL2170435 | 0.85 | NQO2 (0.45) | NPC1NQO2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL15660591 | 0.81 | IMPDH2 (0.51) | ALDH1A1RPS6KB1EGFRMAOAHPGDS | |
| SCHEMBL666625 | 0.77 | RPS6KB1 (0.47) | RPS6KB1 | |
| SCHEMBL2171215 | 0.75 | HPGDS (0.55) | NPC1NQO2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL29831692 | 0.75 | EGFR (0.47) | NQO2CYP1A2CYP3A4HSD17B10ALDH1A1 | |
| SCHEMBL10957530 | 0.73 | EGFR (0.45) | CYP1A2CYP3A4HSD17B10ALDH1A1EGFR | |
| Hydrochloric Acid SCHEMBL28192307 | 0.73 | HPGDS (0.54) | NPC1NQO2CYP1A2CYP3A4HSD17B10 | |
| Hydrochloric Acid SCHEMBL5736824 | 0.73 | EGFR (0.46) | NPC1NQO2CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL1506959 | 0.71 | HTR1A (0.53) | NPC1HSD17B10ALDH1A1HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10781183-B2 | Small molecule inducers of reactive oxygen species and inhibitors of mitochondrial activity | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-09-22 | — | — | US | disclosed |
| US-10781183-B2 | Small molecule inducers of reactive oxygen species and inhibitors of mitochondrial activity | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-09-22 | — | — | US | disclosed |
| US-20190308942-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-10 | — | — | US | disclosed |
| US-20190308942-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-10 | — | — | US | disclosed |
| CN-109328062-A | Small molecule active oxygen cluster inducer and mitochondria activity inhibitor | 密执安大学评议会 | 2019-02-12 | — | — | CN | disclosed |
| EP-3426249-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | The Regents of The University of Michigan (US) | 2019-01-16 | — | — | EP | disclosed |
| US-20180148437-A1 | Novel Ezrin Inhibitors and Methods of Making and Using | UNITED STATES GOVERNMENT | 2018-05-31 | — | — | US | disclosed |
| US-20180148437-A1 | Novel Ezrin Inhibitors and Methods of Making and Using | UNITED STATES GOVERNMENT | 2018-05-31 | — | — | US | disclosed |
| WO-2017155991-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-09-14 | — | — | WO | disclosed |
| WO-2017155991-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2017-09-14 | — | — | WO | disclosed |
| US-9522908-B2 | Ezrin inhibitors and methods of making and using | Gerogetown University (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522908-B2 | Ezrin inhibitors and methods of making and using | Gerogetown University (US) | 2016-12-20 | — | — | US | disclosed |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2014-05-15 | — | — | US | disclosed |
| WO-2012064396-A9 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2012-07-05 | — | — | WO | disclosed |
| WO-2012064396-A2 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | GEORGETOWN UNIVERSITY (US) | 2012-05-18 | — | — | WO | disclosed |
| CN-102459249-A | Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases | EXELIXIS INC | 2012-05-16 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148437-A1 | Novel Ezrin Inhibitors and Methods of Making and Using | EZR, CDC42, ERMP1 | NPC1 815/4885NQO2 1003/4885CYP1A2 4699/4885 |
| US-20190308942-A1 | SMALL MOLECULE INDUCERS OF REACTIVE OXYGEN SPECIES AND INHIBITORS OF MITOCHONDRIAL ACTIVITY | SQOR, MAVS, TFAM | NPC1 3235/4885NQO2 92/4885CYP1A2 1522/4885 |
| US-20140135325-A1 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING | EZR, NHERF1, ERMP1 | NPC1 914/4885NQO2 1074/4885CYP1A2 4642/4885 |
| US-10781183-B2 | Small molecule inducers of reactive oxygen species and inhibitors of mitochondrial activity | SQOR, MAVS, TFAM | NPC1 3235/4885NQO2 92/4885CYP1A2 1522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.