Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882016 | 0.90 | HRH3 (0.41) | HRH3CHRNB2CHRNA7CHRNA4USP30 | |
| SCHEMBL7608784 | 0.81 | CHRNA7 (0.52) | CHRNA7 | |
| SCHEMBL6884176 | 0.81 | CHRNA7 (0.52) | CHRNA7 | |
| SCHEMBL6881244 | 0.79 | HTT (0.49) | HRH3CHRNB2CHRNA7CHRNA4HTT | |
| SCHEMBL7687686 | 0.76 | NPC1 (0.46) | CHRNB2CHRNA7CHRNA4USP30NPC1 | |
| SCHEMBL6883061 | 0.74 | ALDH1A1 (0.41) | CHRNB2CHRNA7CHRNA4USP30HTT | |
| SCHEMBL6881539 | 0.74 | MEN1 (0.46) | HRH3CHRNB2CHRNA7CHRNA4USP30 | |
| SCHEMBL6882177 | 0.74 | PGR (0.51) | CHRNB2CHRNA7CHRNA4NPC1PGR | |
| SCHEMBL7064035 | 0.74 | CHRNA7 (0.37) | HRH3CHRNB2CHRNA7CHRNA4DHX9 | |
| SCHEMBL7125039 | 0.74 | HTT (0.44) | HRH3HTTDHX9MAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002016356-A2 | QUINUCLIDINE-SUBSTITUTED ARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS) | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |