SCHEMBL7703671

SCHEMBL7703671

CCOc1cccc2oc(C(N)=O)cc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.56
ALDH1A1 P00352 3/20 0.49
MAPK10 P53779 2/20 0.49
KMT2A Q03164 2/20 0.47
NMT2 O60551 1/20 0.46
NMT1 P30419 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C19 P33261 1/20 0.46
PARP1 P09874 1/20 0.44
AKR1C1 Q04828 1/20 0.44
TSHR P16473 1/20 0.43
SLC9A1 P19634 1/20 0.42
POLB P06746 1/20 0.42
MAPK1 P28482 1/20 0.42
MAPT P10636 3/20 0.42
HPGD P15428 2/20 0.42
LMNA P02545 1/20 0.42
TP53 P04637 1/20 0.42
ALOX15 P16050 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7706280 0.85 CYP2A6 (0.52) CYP2A6ALDH1A1MAPK10NMT2NMT1
Dimethylamine SCHEMBL4816250 0.85 CYP2A6 (0.52) CYP2A6ALDH1A1MAPK10KMT2ANMT2
Hydrochloric Acid SCHEMBL7701263 0.84 CYP2A6 (0.51) CYP2A6ALDH1A1MAPK10NMT2NMT1
SCHEMBL7709279 0.78 KMT2A (0.72) ALDH1A1KMT2ACYP1A2CYP3A4CYP2C19
SCHEMBL8119758 0.78 KMT2A (0.49) CYP2A6ALDH1A1KMT2ACYP1A2CYP3A4
SCHEMBL15357291 0.76 CYP2A6 (0.50) CYP2A6ALDH1A1KMT2ANMT2NMT1
SCHEMBL27252710 0.75 NMT2 (0.57) ALDH1A1KMT2ANMT2NMT1MRGPRX4
SCHEMBL5584443 0.74 LMNA (0.48) CYP2A6ALDH1A1NMT2NMT1TSHR
SCHEMBL15349649 0.74 F2RL3 (0.46) CYP2A6ALDH1A1KMT2ANMT2NMT1
SCHEMBL4105762 0.74 NMT2 (0.54) CYP2A6ALDH1A1NMT2NMT1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0906301-B1 BENZOFURYL DERIVATIVES AND THEIR USE HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-5955495-A BENZOFURAN-2-CARBOXAMIDINE OR 2-CARBOXAMIDOXIME COMPOUNDS USEFUL IN THE CONTROL OR PREVENTION OF ILLNESSES OR DISORDERS OF THE CENTRAL NERVOUS SYSTEM SUCH AS MIGRAINE, SCHIZOPHRENIA, ANXIETY STATES, SLEEP DISORDERS, ANOREXIA, ALZHEIMER'S HOFFMANN-LA ROCHE INC. (US) 1999-09-21 US disclosed
EP-0906301-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1999-04-07 EP disclosed
WO-1997042183-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1997-11-13 WO disclosed