Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.43 |
| ▸ | KDM5C | P41229 | 5/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.39 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.39 |
| ▸ | KDM6B | O15054 | 2/20 | 0.39 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.38 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 3/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31704070 | 0.83 | KDM4C (0.60) | KDM4EALDH1A1KDM4CKDM5CKDM2A | |
| SCHEMBL6610117 | 0.83 | VCP (0.53) | KDM4EALDH1A1HPGDVCPMTOR | |
| Hydrochloric Acid SCHEMBL7463654 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1KDM4CKDM5CKDM2A | |
| SCHEMBL15907858 | 0.70 | KDM4E (0.57) | KDM4EALDH1A1KDM4CKDM5CKDM2A | |
| SCHEMBL7298838 | 0.69 | KDM4E (0.55) | KDM4EALDH1A1VCPMTORADK | |
| SCHEMBL5491437 | 0.68 | — | — | |
| SCHEMBL743343 | 0.68 | NPC1 (0.43) | KDM4EALDH1A1GAASMN1; SMN2HTT | |
| SCHEMBL6168413 | 0.67 | MYC (0.47) | KDM4EALDH1A1KDM4CKDM5CKDM2A | |
| SCHEMBL27597132 | 0.67 | MAPT (0.53) | KDM4EALDH1A1KMOGAA | |
| SCHEMBL13096285 | 0.66 | CCR1 (0.59) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |