Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | NGFR | P08138 | 1/20 | 0.65 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.62 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 5/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | CA12 | O43570 | 3/20 | 0.60 |
| ▸ | CA1 | P00915 | 3/20 | 0.60 |
| ▸ | CA2 | P00918 | 3/20 | 0.60 |
| ▸ | CA9 | Q16790 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | RAD52 | P43351 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709452 | 0.88 | MEN1 (0.58) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL28125149 | 0.87 | MEN1 (0.64) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL12237994 | 0.85 | FTO (0.69) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL1901643 | 0.82 | FTO (0.72) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL11438964 | 0.82 | FTO (0.68) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL717142 | 0.82 | CA12 (0.74) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL9550381 | 0.82 | NTRK1 (0.61) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL13495360 | 0.82 | FTO (0.61) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL5116172 | 0.81 | MEN1 (0.66) | MEN1KMT2ANTRK1NGFRFTO | |
| SCHEMBL14159191 | 0.81 | CA12 (0.73) | MEN1KMT2ANTRK1NGFRFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | claimed |
| EP-0939754-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-09-08 | — | — | EP | claimed |
| WO-1998019648-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | claimed |
| US-20230128889-A1 | REL/RELA/SPOT SMALL MOLECULES MODULATORS AND SCREENING METHODS | Université Libre de Bruxelles (BE) | 2023-04-27 | — | — | US | disclosed |
| US-20230128889-A1 | REL/RELA/SPOT SMALL MOLECULES MODULATORS AND SCREENING METHODS | Université Libre de Bruxelles (BE) | 2023-04-27 | — | — | US | disclosed |
| CN-110041202-B | Preparation method of 1, 8-disubstituted naphthalene mononitration derivative | 长江大学 | 2022-04-19 | — | — | CN | disclosed |
| CN-110041203-A | A kind of 1,8- bis- replaces the preparation method of naphthalene system condensed-nuclei aromatics mono-nitration derivative | 长江大学 | 2019-07-23 | — | — | CN | disclosed |
| CN-110041202-A | A kind of 1,8- bis- replaces the preparation method of naphthalene mono-nitration derivative | 长江大学 | 2019-07-23 | — | — | CN | disclosed |
| WO-2014179528-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS | BROWN DENNIS M (US) | 2014-11-06 | — | — | WO | disclosed |
| WO-2013059582-A2 | SMALL MOLECULE INHIBITORS OF HISTONE DEACTEYLASES | NUPOTENTIAL, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| US-20110262383-A1 | Naphthalimide Dosing by N-Acetyl Transferase Genotyping | CHEMGENEX PHARMACEUTICALS, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| EP-2305257-A1 | Amonafide salts and compositions comprising same | ChemGenex Pharmaceuticals, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| US-20110003742-A1 | Naphthalimide Dosing by N-Acetyl Transferase Genotyping | CHEMGENEX PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | US | disclosed |
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0939754-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998019648-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |
| US-5237059-A | Compounds capable of generating an acid by light irradiation | FUJI PHOTO FILM CO., LTD. (JP) | 1993-08-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110262383-A1 | Naphthalimide Dosing by N-Acetyl Transferase Genotyping | NAT1, NCF1, GGCT | MEN1 3298/4885KMT2A 1648/4885NTRK1 1473/4885 |
| US-20110003742-A1 | Naphthalimide Dosing by N-Acetyl Transferase Genotyping | NAT1, NCF1, GGCT | MEN1 3298/4885KMT2A 1648/4885NTRK1 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.