Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 11/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709573 | 0.78 | TACR1 (0.55) | TACR1 | |
| SCHEMBL6016452 | 0.77 | MYC (0.44) | KMT2AALDH1A1POLB | |
| SCHEMBL6016367 | 0.70 | TACR1 (0.47) | TACR1KMT2AHSP90AA1HSP90AB1 | |
| SCHEMBL5779692 | 0.67 | TACR1 (0.73) | TACR1GPBAR1 | |
| SCHEMBL5759212 | 0.66 | TACR1 (0.72) | TACR1GPBAR1 | |
| SCHEMBL5781114 | 0.66 | TACR1 (0.72) | TACR1GPBAR1 | |
| SCHEMBL6016449 | 0.65 | GPBAR1 (0.38) | KMT2AMEN1ALDH1A1GPBAR1 | |
| SCHEMBL5966320 | 0.65 | TACR1 (0.72) | TACR1KMT2AGPBAR1 | |
| SCHEMBL5966363 | 0.65 | TACR1 (0.76) | TACR1KMT2AGPBAR1 | |
| SCHEMBL5784269 | 0.65 | TACR1 (0.71) | TACR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187815-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000073279-A1 | 4-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |