Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 12/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.33 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696186 | 1.00 | MTNR1B (0.39) | MTNR1BSLC9A1KDM4EMTNR1APTPN1 | |
| SCHEMBL7696185 | 1.00 | MTNR1B (0.39) | MTNR1BSLC9A1KDM4EMTNR1APTPN1 | |
| SCHEMBL6274303 | 0.83 | SLC9A1 (0.35) | MTNR1BSLC9A1KDM4EMTNR1AHTR2A | |
| SCHEMBL6274305 | 0.83 | SLC9A1 (0.35) | MTNR1BSLC9A1KDM4EMTNR1AHTR2A | |
| SCHEMBL23430249 | 0.83 | MTNR1B (0.39) | MTNR1BSLC9A1KDM4EMTNR1ASLC9A5 | |
| SCHEMBL1536429 | 0.75 | KDM4E (0.65) | MTNR1BSLC9A1KDM4EMTNR1ASLC9A5 | |
| SCHEMBL1536428 | 0.75 | KDM4E (0.65) | MTNR1BSLC9A1KDM4EMTNR1ASLC9A5 | |
| SCHEMBL12809257 | 0.75 | CDK4 (0.42) | MTNR1BSLC9A1KDM4EMTNR1ADRD2 | |
| SCHEMBL19480305 | 0.75 | ITGB2 (0.34) | MTNR1BSLC9A1KDM4EMTNR1ASLC9A5 | |
| SCHEMBL6271153 | 0.74 | HTR2C (0.41) | MTNR1BKDM4EMTNR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082115-A4 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2002-10-24 | — | — | EP | disclosed |
| US-6214869-B1 | SLEEP DISORDERS | BRISTOL-MYERS SQUIBB | 2001-04-10 | — | — | US | disclosed |
| EP-1082115-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062515-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-09 | — | — | WO | disclosed |