Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | VEGFA | P15692 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553511 | 1.00 | PDE4A (0.48) | PDE4APDE4BPDE4DPDE4CMTNR1A | |
| SCHEMBL2556779 | 0.92 | PDE4A (0.40) | PDE4APDE4BPDE4DPDE4CMTNR1A | |
| SCHEMBL7711514 | 0.88 | MTNR1A (0.45) | PDE4APDE4BPDE4DPDE4CMTNR1A | |
| SCHEMBL2559533 | 0.86 | PDE4A (0.44) | PDE4APDE4BPDE4DPDE4CMTNR1A | |
| SCHEMBL2561373 | 0.82 | PDE4A (0.47) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2560575 | 0.81 | PDE4B (0.46) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2563217 | 0.80 | PDE10A (0.49) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2558454 | 0.80 | PDE4B (0.49) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2560888 | 0.79 | PDE10A (0.48) | PDE4APDE4BPDE4DPDE4CPDE10A | |
| SCHEMBL2556896 | 0.78 | PDE10A (0.49) | PDE4APDE4BPDE4DPDE4CPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |