Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.56 |
| ▸ | NMT1 | P30419 | 4/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.43 |
| ▸ | FEN1 | P39748 | 5/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15134886 | 0.99 | PDE10A (0.55) | PDE10ANMT1ALOX5APFEN1FFAR4 | |
| SCHEMBL7710439 | 0.82 | PDE10A (0.53) | PDE10ATLR9TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL15134941 | 0.81 | PDE10A (0.52) | PDE10ATLR9TLR8TLR7 | |
| SCHEMBL4111572 | 0.77 | HTR1A (0.55) | PDE10ANMT1HRH1CARM1 | |
| Hydrochloric Acid SCHEMBL21752568 | 0.76 | HTR1A (0.53) | PDE10ANMT1HRH1CARM1 | |
| SCHEMBL6844999 | 0.75 | DYRK1A (0.51) | PDE10AALOX5APFEN1FFAR4 | |
| SCHEMBL15917169 | 0.74 | NMT1 (0.46) | NMT1HRH1 | |
| SCHEMBL12696756 | 0.74 | ROCK1 (0.55) | TLR9TLR8TLR7HRH1 | |
| SCHEMBL15916845 | 0.73 | ALOX5AP (0.79) | ALOX5APFEN1 | |
| SCHEMBL7693732 | 0.72 | PDE10A (1.00) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| WO-2011143495-A1 | HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |