Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15134941 | 0.99 | PDE10A (0.52) | PDE10ATLR7TLR8TLR9LRRK2 | |
| SCHEMBL17456029 | 0.83 | PDE10A (0.47) | PDE10ALRRK2 | |
| SCHEMBL7704633 | 0.82 | PDE10A (0.56) | PDE10ATLR7TLR8TLR9 | |
| Hydrochloric Acid SCHEMBL15134886 | 0.81 | PDE10A (0.55) | PDE10ATLR7TLR8TLR9 | |
| SCHEMBL12696756 | 0.76 | ROCK1 (0.55) | TLR7TLR8TLR9 | |
| Hydrochloric Acid SCHEMBL17456014 | 0.74 | PRKCI (0.50) | PDE10A | |
| SCHEMBL2631068 | 0.73 | PDE10A (0.82) | PDE10A | |
| SCHEMBL2630915 | 0.70 | PDE10A (0.51) | PDE10A | |
| SCHEMBL4111572 | 0.70 | HTR1A (0.55) | PDE10A | |
| SCHEMBL2631010 | 0.69 | PDE10A (1.00) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-9376450-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8497265-B2 | Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors | AMGEN INC. (US) | 2013-07-30 | — | — | US | disclosed |
| WO-2011143495-A1 | HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |