Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | F11 | P03951 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710592 | 0.87 | ADRA1D (0.46) | GPR119TSHRALOX15ATMPDK2 | |
| SCHEMBL12877871 | 0.87 | PDK2 (0.44) | GPR119TSHRALOX15ATMPDK2 | |
| SCHEMBL20140553 | 0.87 | GPR119 (0.50) | GPR119TSHRALOX15ATMEGLN2 | |
| SCHEMBL29446735 | 0.86 | GPR119 (0.44) | GPR119TSHRALOX15ATMPDK2 | |
| SCHEMBL21855700 | 0.86 | PDK2 (0.43) | GPR119TSHRALOX15ATMPDK2 | |
| SCHEMBL4362609 | 0.86 | GPR119 (0.44) | GPR119TSHRALOX15ATMPDK2 | |
| SCHEMBL29505978 | 0.86 | PDK2 (0.43) | GPR119TSHRALOX15ATMPDK2 | |
| SCHEMBL31158306 | 0.86 | ADRA1D (0.45) | GPR119TSHRALOX15ATMPDK2 | |
| SCHEMBL1513325 | 0.86 | ADRA1D (0.45) | GPR119TSHRALOX15ATMPDK2 | |
| SCHEMBL3254660 | 0.85 | ADRA1D (0.47) | GPR119TSHRALOX15ATMPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358959-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-03-19 | — | — | US | disclosed |
| US-6319932-B1 | USEFUL FOR TREATING BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-11-20 | — | — | US | disclosed |
| US-6228870-B1 | BENIGN PROSTATIC HYPERPLASIA; REDUCTION OF HYPOTENSION SIDE EFFECT | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |
| WO-2000043374-A1 | POLYAZANAPHTHALENONE DERIVATIVES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000027817-A1 | OXAZOLIDINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000027827-A1 | OXAZOLIDINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-18 | — | — | WO | disclosed |