Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704732 | 1.00 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5873928 | 0.87 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5873925 | 0.87 | ALDH1A1 (0.37) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5244459 | 0.84 | AGTR1 (0.40) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5873918 | 0.84 | AGTR1 (0.40) | SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5873981 | 0.82 | MOGAT2 (0.33) | — | |
| SCHEMBL5894115 | 0.82 | MOGAT2 (0.33) | — | |
| SCHEMBL5894696 | 0.81 | EIF2AK2 (0.47) | ALDH1A1MAPT | |
| SCHEMBL5894679 | 0.81 | EIF2AK2 (0.47) | ALDH1A1MAPT | |
| SCHEMBL5894025 | 0.77 | KMT2A (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | disclosed |