Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28278160 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL28278157 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL7348161 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL7339341 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL19745716 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL7340676 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL7344423 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL7338476 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL7377007 | 0.81 | MAOA (0.67) | MAOAMAOBMEN1KMT2AEPHX1 | |
| SCHEMBL26511667 | 0.81 | CES2 (0.52) | CES2MEN1KMT2ATHRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263730-A1 | AMINE DERIVATIVES FOR THE TREATMENT OF APOPTOSIS | Applied Research Systems ARS Holding N.V. (AN) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001060798-A1 | AMINE DERIVATIVES FOR THE TREATMENT OF APOPTOSIS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-08-23 | — | — | WO | disclosed |