Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705141 | 1.00 | HTT (0.38) | HTTKDM4EGAATSHR | |
| SCHEMBL633115 | 0.83 | HTT (0.42) | HTTKDM4EGAATSHR | |
| SCHEMBL7700122 | 0.79 | HTT (0.36) | HTTKDM4EGAA | |
| SCHEMBL7700129 | 0.76 | KDM4E (0.36) | HTTKDM4EGAA | |
| SCHEMBL7700127 | 0.76 | KDM4E (0.36) | HTTKDM4EGAA | |
| SCHEMBL2591258 | 0.74 | GAA (0.49) | HTTKDM4EGAATSHR | |
| SCHEMBL2383891 | 0.69 | HTT (0.44) | HTTKDM4EGAATSHR | |
| SCHEMBL6755229 | 0.69 | HTT (0.44) | HTTKDM4EGAATSHR | |
| SCHEMBL4045244 | 0.69 | HTT (0.44) | HTTKDM4EGAATSHR | |
| SCHEMBL9734970 | 0.69 | HTT (0.41) | HTTKDM4EGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355665-B1 | ANTIHISTAMINES, ANTIALLERGENS AND IRRITABLE BOWEL SYNDROME. | JAMES BLACK FOUNDATION LIMITED (GB) | 2002-03-12 | — | — | US | disclosed |
| WO-1999005114-A2 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-02-04 | — | — | WO | disclosed |