Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | F11 | P03951 | 1/20 | 0.43 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707683 | 0.84 | TACR1 (0.55) | KCNH2 | |
| SCHEMBL16396757 | 0.77 | CFD (0.62) | CFDF11TPSB2PTGER1PTGER4 | |
| SCHEMBL7705623 | 0.75 | TACR1 (0.56) | KCNH2 | |
| SCHEMBL7705827 | 0.73 | TACR1 (0.56) | KCNH2SIGMAR1 | |
| SCHEMBL7705390 | 0.73 | TACR1 (0.60) | KCNH2SIGMAR1 | |
| SCHEMBL7699781 | 0.72 | TACR1 (0.61) | KCNH2ALDH1A1PTPN2PTPN1 | |
| SCHEMBL7699901 | 0.72 | TACR1 (0.59) | KCNH2SIGMAR1 | |
| SCHEMBL16396440 | 0.71 | CFD (0.59) | CFDF11TPSB2PTGER1PTGER4 | |
| SCHEMBL16397056 | 0.71 | CFD (0.49) | CFDF11TPSB2ALDH1A1PTGER1 | |
| SCHEMBL7704886 | 0.71 | TACR1 (0.48) | PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242399-A1 | $g(a)-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS | UCB S.A. (BE) | 2002-09-25 | — | — | EP | claimed |
| WO-2001046167-A1 | α-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS | UCB, S.A. (BE) | 2001-06-28 | — | — | WO | claimed |