SCHEMBL7705653

SCHEMBL7705653

O=C(NCCc1ccccc1)c1ccc(CN2CCOCC2)cc1

nearest known ligand 0.77

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.77
KDM4E B2RXH2 2/20 0.75
NPC1 O15118 2/20 0.71
RAB9A P51151 2/20 0.71
KMT2A Q03164 1/20 0.68
HIF1A Q16665 1/20 0.67
EPAS1 Q99814 1/20 0.67
SMN1; SMN2 Q16637 4/20 0.67
LMNA P02545 3/20 0.67
POLB P06746 1/20 0.64
GAA P10253 1/20 0.64
HPGD P15428 1/20 0.60
CD274 Q9NZQ7 1/20 0.60
MAPT P10636 1/20 0.60
MCHR1 Q99705 3/20 0.60
CYP2D6 P10635 1/20 0.60
CHRM1 P11229 1/20 0.60
HTR2A P28223 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7703379 0.85 HDAC6 (0.64) KDM4ENPC1RAB9ASMN1; SMN2LMNA
SCHEMBL6250979 0.85 MCHR1 (0.70) ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL14456882 0.85 MCHR1 (0.60) ALDH1A1KDM4ENPC1RAB9ASMN1; SMN2
SCHEMBL6250405 0.84 MCHR1 (0.73) KDM4ESMN1; SMN2MCHR1CYP2D6CHRM1
SCHEMBL27628793 0.83 ALDH1A1 (0.92) ALDH1A1KDM4ENPC1RAB9AKMT2A
SCHEMBL10272436 0.83 KMT2A (0.77) ALDH1A1KDM4ENPC1RAB9AKMT2A
SCHEMBL23014409 0.82 ALDH1A1 (0.73) ALDH1A1KDM4ENPC1RAB9AKMT2A
SCHEMBL3868266 0.82 MCHR1 (0.82) KMT2ASMN1; SMN2MCHR1CYP2D6CHRM1
SCHEMBL21657710 0.81 HIF1A (1.00) ALDH1A1NPC1RAB9AKMT2AHIF1A
SCHEMBL3869826 0.80 MCHR1 (0.66) KDM4ESMN1; SMN2MCHR1CYP2D6CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0901488-B1 2,4-DIAMINOPYRIMIDINE DERIVATIVES BASILEA PHARMACEUTICA AG (CH) 2002-11-06 EP disclosed
EP-0901488-A1 2,4-DIAMINOPYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-03-17 EP disclosed
US-5866583-A Substituted 2,4-diaminopyrimidines HOFFMANN-LA ROCHE INC. (US) 1999-02-02 US disclosed
WO-1997043277-A1 2,4-DIAMINOPYRIMIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1997-11-20 WO disclosed