Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | HTR1A | P08908 | 6/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704875 | 0.95 | DRD2 (0.54) | KDM4ELMNAALOX15DRD2HTR1A | |
| SCHEMBL544948 | 0.90 | HTR1D (0.54) | DRD2HTR1AHTR2ASLC6A4HTR6 | |
| Hydrochloric Acid SCHEMBL6676940 | 0.90 | HTR1D (0.54) | DRD2HTR1AHTR2ASLC6A4HTR6 | |
| SCHEMBL5398831 | 0.90 | HTR1D (0.54) | DRD2HTR1AHTR2ASLC6A4HTR6 | |
| SCHEMBL5386204 | 0.90 | HTR1D (0.54) | DRD2HTR1AHTR2ASLC6A4HTR6 | |
| Hydrochloric Acid SCHEMBL6676944 | 0.90 | HTR1D (0.54) | DRD2HTR1AHTR2ASLC6A4HTR6 | |
| SCHEMBL7220005 | 0.88 | DRD2 (0.46) | KDM4ELMNAALOX15DRD2HTR1A | |
| SCHEMBL7213885 | 0.87 | HTR1A (0.43) | KDM4ELMNAALOX15DRD2HTR1A | |
| SCHEMBL7213933 | 0.85 | HTR1D (0.51) | DRD2HTR1ASLC6A4HTR6 | |
| SCHEMBL7213708 | 0.85 | HTR1D (0.54) | KDM4ELMNAALOX15DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6352988-B2 | HIGH AFFINITY FOR D4 RECEPTORS; TREATMENT OF SCHIZOPHRENIA, OTHER PSYCHOSES, ANXIETY DISORDERS, DEPRESSION, ALCOHOL ABUSE, IMPULSE CONTROL DISORDERS, AGGRESSION | H. LUNDBECK A/S (DK) | 2002-03-05 | — | — | US | disclosed |