Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CHRNG | P07510 | 1/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CHRND | Q07001 | 1/20 | 0.42 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9900635 | 0.84 | HTR3A (0.38) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL9901829 | 0.84 | HTR3A (0.38) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL30673624 | 0.84 | HTR3A (0.38) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL9900173 | 0.81 | BTK (0.46) | — | |
| SCHEMBL9900029 | 0.81 | BTK (0.46) | — | |
| SCHEMBL9900636 | 0.79 | NEK2 (0.34) | — | |
| SCHEMBL30154873 | 0.79 | NEK2 (0.34) | — | |
| SCHEMBL28076460 | 0.79 | HRH4 (0.41) | HRH3TNK2 | |
| SCHEMBL14440475 | 0.75 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL7699577 | 0.74 | CHRNB2 (0.42) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143365-A1 | NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |