Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.49 |
| ▸ | GRM5 | P41594 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708907 | 0.90 | ADORA2A (0.52) | ADORA2AGRM5NPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7705856 | 0.88 | ADORA2A (0.54) | ADORA2AGRM5NPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7703127 | 0.85 | ADORA2A (0.52) | ADORA2AGRM5NPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7703193 | 0.85 | ADORA2A (0.46) | ADORA2AGRM5NPC1SMN1; SMN2MAPT | |
| SCHEMBL7427435 | 0.85 | ADORA2A (0.54) | ADORA2AGRM5NPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7708837 | 0.83 | GRM5 (0.52) | ADORA2AGRM5NPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7428533 | 0.82 | ADORA2A (0.60) | ADORA2ANPC1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL7426515 | 0.82 | ADORA2A (0.51) | ADORA2AGRM5NPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7708776 | 0.82 | ADORA2A (0.53) | ADORA2AGRM5NPC1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7708534 | 0.82 | ADORA2A (0.53) | ADORA2AGRM5NPC1L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |