SCHEMBL7705906

SCHEMBL7705906

COc1ccc(-c2c(Oc3ccccc3)cc3cc(OC)ccc3c2O)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.44
BACE1 P56817 1/20 0.43
MAOB P27338 1/20 0.43
KDM4E B2RXH2 4/20 0.43
ALDH1A1 P00352 4/20 0.43
MAPT P10636 3/20 0.43
LMNA P02545 2/20 0.43
HPGD P15428 2/20 0.43
HTT P42858 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
NPC1 O15118 1/20 0.43
NFKB1 P19838 1/20 0.43
RAB9A P51151 1/20 0.43
NFKB2 Q00653 1/20 0.43
RELA Q04206 1/20 0.43
ATM Q13315 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
ALOX5 P09917 1/20 0.42
ERN1 O75460 1/20 0.41
CYP1A2 P05177 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3168976 0.78 CYP1A2 (0.49) BACE1MAOBKDM4EALDH1A1MAPT
SCHEMBL3178792 0.77 MAOB (0.46) MAOBKDM4EALDH1A1MAPTHPGD
SCHEMBL3173270 0.75 ALOX5 (0.48) BACE1MAOBALDH1A1ALOX5CYP1A2
SCHEMBL3171982 0.75 ALOX5 (0.45) BACE1KDM4EALDH1A1MAPTHPGD
SCHEMBL3176269 0.73 ESR1 (0.45) BACE1ALDH1A1ALOX5CYP1A2CYP2C9
SCHEMBL3178057 0.73 ESR1 (0.49) BACE1KDM4EALDH1A1MAPTHPGD
SCHEMBL3182854 0.72 ESR1 (0.52) BACE1ALDH1A1ALOX5CYP1A2CYP2C9
SCHEMBL29120671 0.72 ALOX5 (0.53) BACE1KDM4EALDH1A1MAPTLMNA
SCHEMBL3162945 0.71 ACLY (0.43) KDM4EALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL6088276 0.71 SMN1; SMN2 (0.49) BACE1KDM4EALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6355632-B1 AROMATIC ETHER AMINES FOR TREATMENT OF OSTEOPOROSIS ELI LILLY AND COMPANY 2002-03-12 US disclosed
US-6268361-B1 ESTROGEN DEPENDENT DISORDERS INCLUDING CANCER, ENODMETRIOSIS, ETC PALKOWITZ ALAN D (US) 2001-07-31 US disclosed
US-5998401-A POSTMENOPAUSE THERAPY ELI LILLY AND COMPANY (US) 1999-12-07 US disclosed
US-5574190-A AROMATIC ETHER DERIVATIVES FOR TREATMENT OF HORMONE DEPENDENT CANCER SUCH AS BREAST CANCER ELI LILLY AND COMPANY (US) 1996-11-12 US disclosed