SCHEMBL7706053

SCHEMBL7706053

COc1cccc(C(NC[C@H]2O[C@@H](n3cc(C)c(=O)[nH]c3=O)C[C@@H]2OP(N)O)(c2ccccc2)c2ccccc2)c1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.46
DUT P33316 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL152181 0.93 RNASE1 (0.48) RNASE1DUT
SCHEMBL3923808 0.87 DUT (0.59) DUT
SCHEMBL9341952 0.85 RNASE1 (0.46) RNASE1DUT
SCHEMBL152180 0.83 DUT (0.58) DUT
SCHEMBL9342953 0.83 RNASE1 (0.44) RNASE1DUT
SCHEMBL6514624 0.81 RNASE1 (0.47) RNASE1DUT
SCHEMBL9342955 0.80 RNASE1 (0.42) RNASE1DUT
SCHEMBL6514654 0.80 RNASE1 (0.48) RNASE1
SCHEMBL6536529 0.80 RNASE1 (0.48) RNASE1
SCHEMBL22819137 0.80 DUT (0.49) RNASE1DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020068275-A1 METHODS OF USING A CHIMERIC NUCLEIC ACID/NUCLEIC ACID ANALOGUE MOLECULE AMERSHAM INTERNATIONAL PLC (GB) 2002-06-06 US disclosed
EP-0720615-B1 ELONGATION, AMPLIFICATION AND SEQUENCE DETERMINATION USING A CHIMERIC OLIGONUCLEOTIDE AMERSHAM PHARM BIOTECH UK LTD (GB) 2000-07-26 EP disclosed
EP-0720615-A1 REAGENTS COMPRISING CHIMERIC MOLECULES OF NUCLEIC ACIDS AND NUCLEIC ACID ANALOGS AMERSHAM INTERNATIONAL plc (GB) 1996-07-10 EP disclosed
WO-1995008556-A1 REAGENTS COMPRISING CHIMERIC MOLECULES OF NUCLEIC ACIDS AND NUCLEIC ACID ANALOGS AMERSHAM INTERNATIONAL PLC (GB) 1995-03-30 WO disclosed