Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL7706205 | 1.00 | TSHR (0.32) | TSHRUSP2SLC6A2SLC6A4BLM | |
| SCHEMBL165599 | 0.78 | — | — | |
| SCHEMBL8902693 | 0.76 | CYP2D6 (0.41) | TSHRSLC6A2SLC6A4BLMSLC6A3 | |
| Hydrochloric Acid SCHEMBL791648 | 0.76 | — | — | |
| Glycine SCHEMBL3706934 | 0.74 | GLRA1 (0.48) | TSHRSLC6A2SLC6A4BLMSLC6A3 | |
| Ammonia Solution, Strong SCHEMBL28014704 | 0.74 | — | — | |
| D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL2553076 | 0.73 | TSHR (0.56) | TSHRUSP2BLMSLCO1B1MEN1 | |
| D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL1130719 | 0.73 | TSHR (0.56) | TSHRUSP2BLMSLCO1B1MEN1 | |
| D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL336363 | 0.73 | TSHR (0.56) | TSHRUSP2BLMSLCO1B1MEN1 | |
| D,L-Threo-3-Hydroxyaspartic Acid SCHEMBL5019049 | 0.73 | TSHR (0.56) | TSHRUSP2BLMSLCO1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6429288-B1 | OSTEOPOROSIS, OSTEOARTHRITIS, AND RHEUMATIC DISEASES | ROCHE DIAGNOSTICS GMBH (DE) | 2002-08-06 | — | — | US | disclosed |