Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142666 | 0.94 | PTGDR2 (0.36) | PTGDR2TRPM4 | |
| SCHEMBL7149260 | 0.92 | RORC (0.37) | PTGDR2FFAR1 | |
| SCHEMBL7141229 | 0.91 | HTT (0.37) | — | |
| SCHEMBL7142827 | 0.91 | KMT2A (0.43) | — | |
| SCHEMBL7146923 | 0.89 | SLC16A3 (0.36) | — | |
| SCHEMBL7142019 | 0.85 | GSK3B (0.36) | — | |
| SCHEMBL7140136 | 0.85 | GSK3B (0.36) | FFAR1 | |
| SCHEMBL6164750 | 0.85 | PTGES (0.38) | — | |
| SCHEMBL7143481 | 0.84 | RORC (0.35) | — | |
| SCHEMBL5868814 | 0.84 | PTGES (0.41) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |