Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 2/20 | 0.30 |
| ▸ | FLT4 | P35916 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
| ▸ | FLT3 | P36888 | 2/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 2/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706676 | 1.00 | RET (0.39) | RETTDP2CSF1RALDH1A1MAPT | |
| SCHEMBL5432281 | 0.86 | MAOA (0.42) | RETCSF1RPIM1RPS6KA3CHEK1 | |
| SCHEMBL5432283 | 0.86 | MAOA (0.42) | RETCSF1RPIM1RPS6KA3CHEK1 | |
| SCHEMBL5873761 | 0.83 | RET (0.33) | RETTDP2 | |
| SCHEMBL5873770 | 0.83 | RET (0.33) | RETTDP2 | |
| SCHEMBL5183175 | 0.82 | MAOA (0.38) | RETCSF1RMAPTPIM1RPS6KA3 | |
| SCHEMBL5183182 | 0.82 | MAOA (0.38) | RETCSF1RMAPTPIM1RPS6KA3 | |
| SCHEMBL5182966 | 0.81 | PIM1 (0.40) | RETALDH1A1MAPTPIM1KIT | |
| SCHEMBL5182964 | 0.81 | PIM1 (0.40) | RETALDH1A1MAPTPIM1KIT | |
| SCHEMBL7703527 | 0.81 | RET (0.46) | RETTDP2CSF1RALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | claimed |