Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.70 |
| ▸ | FEN1 | P39748 | 2/20 | 0.70 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.70 |
| ▸ | BRD1 | O95696 | 1/20 | 0.53 |
| ▸ | TAF1 | P21675 | 1/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8927321 | 0.85 | BRD1 (0.59) | ERCC1FEN1ERCC4BRD1TAF1 | |
| SCHEMBL10703784 | 0.85 | BRD1 (0.52) | ERCC1FEN1ERCC4BRD1TAF1 | |
| SCHEMBL29410043 | 0.83 | ERCC1 (1.00) | ERCC1FEN1ERCC4MAPTPOLB | |
| SCHEMBL132760 | 0.83 | ERCC1 (1.00) | ERCC1FEN1ERCC4MAPTPOLB | |
| SCHEMBL7706742 | 0.83 | ERCC1 (0.70) | ERCC1FEN1ERCC4MPOMAPT | |
| SCHEMBL7703367 | 0.83 | ERCC1 (0.70) | ERCC1FEN1ERCC4BRD1TAF1 | |
| SCHEMBL7703805 | 0.81 | MPO (0.73) | ERCC1FEN1ERCC4BRD1TAF1 | |
| SCHEMBL19985742 | 0.81 | ERCC1 (0.68) | ERCC1FEN1ERCC4BRD1TAF1 | |
| SCHEMBL4888025 | 0.81 | ERCC1 (0.96) | ERCC1FEN1ERCC4MAPTPOLB | |
| Methane SCHEMBL20512282 | 0.81 | ERCC1 (0.96) | ERCC1FEN1ERCC4MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | claimed |
| WO-2013059582-A2 | SMALL MOLECULE INHIBITORS OF HISTONE DEACTEYLASES | NUPOTENTIAL, INC. (US) | 2013-04-25 | — | — | WO | disclosed |
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0939754-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998019648-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |