Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | TYMS | P04818 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8062355 | 0.83 | KDM4E (0.61) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL5964469 | 0.82 | ALDH1A1 (0.71) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL7709637 | 0.81 | TYMS (0.48) | KDM4EALDH1A1GAATYMSHPGD | |
| SCHEMBL9077602 | 0.81 | TYMS (0.44) | KDM4EALDH1A1GAATYMSHPGD | |
| SCHEMBL9437196 | 0.79 | ALDH1A1 (0.67) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL28655617 | 0.77 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL2134658 | 0.77 | TYMS (0.56) | KDM4EALDH1A1GAATYMSMAPT | |
| SCHEMBL9437176 | 0.76 | ALDH1A1 (0.64) | KDM4EALDH1A1GAAMAPTKMT2A | |
| SCHEMBL11809469 | 0.76 | TYMS (0.51) | KDM4EALDH1A1GAATYMSHPGD | |
| SCHEMBL7706686 | 0.76 | TYMS (0.44) | KDM4EALDH1A1GAATYMSKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0939754-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998019648-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |
| US-4210757-A | Novel naphthoylene-perinones disperse dyestuffs | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |
| US-4067889-A | 2-CYANO-3-AMINO-BENZANTHRONES AS PRECURSORS | CIBA-GEIGY CORPORATION (US) | 1978-01-10 | — | — | US | disclosed |
| US-3970675-A | ANTHRONE-AMIDINE | CIBA-GEIGY CORPORATION (US) | 1976-07-20 | — | — | US | disclosed |