Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 3/20 | 0.43 |
| ▸ | RARB | P10826 | 3/20 | 0.43 |
| ▸ | RARG | P13631 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709737 | 0.94 | RARA (0.43) | RARARARBRARGHSD17B10CYP3A4 | |
| SCHEMBL7709686 | 0.85 | RARA (0.43) | RARARARBRARG | |
| SCHEMBL7709957 | 0.77 | RARA (0.53) | RARARARBRARG | |
| SCHEMBL7709675 | 0.77 | RARA (0.53) | RARARARBRARG | |
| SCHEMBL8293240 | 0.75 | RARA (0.54) | RARARARBRARG | |
| SCHEMBL7712301 | 0.74 | RARA (0.53) | RARARARBRARGCYP3A4 | |
| SCHEMBL15625438 | 0.71 | RARA (0.53) | RARARARBRARGHSD17B10CYP3A4 | |
| SCHEMBL12715253 | 0.71 | RARA (0.53) | RARARARBRARGHSD17B10 | |
| SCHEMBL17675521 | 0.71 | RARA (0.53) | RARARARBRARG | |
| SCHEMBL29539383 | 0.70 | CYP3A4 (0.44) | RARARARBRARGHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6127382-A | AN ANTIPROLIFERATIVE AGENT FOR TREATING SKIN-RELATED DISEASES, AN ANTITUMOR AGENT TREATING CANCER, AN ANTIINFLAMMATORY AGENT TREATING PULMONARY FIBROSIS, ILEITIS, COLITIS AND KROHN'S DISEASE | ALLERGAN SALES, INC. (US) | 2000-10-03 | — | — | US | disclosed |