Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 4/20 | 0.54 |
| ▸ | RARB | P10826 | 4/20 | 0.54 |
| ▸ | RARG | P13631 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24202326 | 0.91 | RARA (0.46) | RARARARBRARGKMT2AKDM4E | |
| SCHEMBL5539777 | 0.83 | RARA (0.39) | RARARARBRARGKMT2AKDM4E | |
| SCHEMBL12715253 | 0.83 | RARA (0.53) | RARARARBRARGOPRM1OPRD1 | |
| SCHEMBL17675521 | 0.83 | RARA (0.53) | RARARARBRARGHDAC1HDAC6 | |
| SCHEMBL7709957 | 0.83 | RARA (0.53) | RARARARBRARGKMT2AKDM4E | |
| SCHEMBL8293242 | 0.78 | RARA (0.48) | RARARARBRARGKMT2AKDM4E | |
| SCHEMBL2625755 | 0.78 | RARA (0.48) | RARARARBRARGKMT2AKDM4E | |
| SCHEMBL7709737 | 0.75 | RARA (0.43) | RARARARBRARGALDH1A1 | |
| SCHEMBL7709686 | 0.75 | RARA (0.43) | RARARARBRARG | |
| SCHEMBL7706875 | 0.75 | RARA (0.43) | RARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833203-B2 | Synthetic retinoids (in cell modulation) | UNIVERSITY OF DURHAM | 2023-12-05 | — | — | US | disclosed |
| US-11324825-B2 | Synthetic retinoids (in cell modulation) | UNIVERSITY OF DURHAM | 2022-05-10 | — | — | US | disclosed |
| US-10759762-B2 | Fluorescent synthetic retinoids | HIGH FORCE RESEARCH LIMITED (GB) | 2020-09-01 | — | — | US | disclosed |
| US-20190209684-A1 | Synthetic Retinoids (in Cell Modulation) | UNIVERSITY OF DURHAM (GB) | 2019-07-11 | — | — | US | disclosed |
| US-20190209685-A1 | SYNTHETIC RETINOIDS (IN CELL MODULATION) | UNIVERSITY OF DURHAM (GB) | 2019-07-11 | — | — | US | disclosed |
| WO-2018029473-A1 | SYNTHETIC RETINOIDS (IN CELL MODULATION) | UNIVERSITY OF DURHAM (GB) | 2018-02-15 | — | — | WO | disclosed |
| US-20170217893-A1 | Fluorescent Synthetic Retinoids | HIGH FORCE RESEARCH LIMITED (GB) | 2017-08-03 | — | — | US | disclosed |
| EP-1692097-B1 | TRICYCLIC HYDROXAMATE AND BENZAMIDE DERIVATIVES, COMPOSITIONS AND METHODS | EXONHIT THERAPEUTICS SA (FR) | 2009-09-02 | — | — | EP | disclosed |
| WO-2005058803-A1 | TRICYCLIC HYDROXAMATE AND BENZAMIDE DERIVATIVES, COMPOSITIONS AND METHODS | EXONHIT THERAPEUTICS SA (FR) | 2005-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10759762-B2 | Fluorescent synthetic retinoids | RARB, RXRB, RXRA | RARA 4/4885RARB 1/4885RARG 5/4885 |
| US-11833203-B2 | Synthetic retinoids (in cell modulation) | RARA, RARB, RXRA | RARA 1/4885RARB 2/4885RARG 4/4885 |
| US-11324825-B2 | Synthetic retinoids (in cell modulation) | RARA, RARB, RXRA | RARA 1/4885RARB 2/4885RARG 4/4885 |
| US-20190209685-A1 | SYNTHETIC RETINOIDS (IN CELL MODULATION) | RARA, RARB, RXRA | RARA 1/4885RARB 2/4885RARG 4/4885 |
| US-20170217893-A1 | Fluorescent Synthetic Retinoids | RARB, RXRB, RXRA | RARA 4/4885RARB 1/4885RARG 5/4885 |
| US-20190209684-A1 | Synthetic Retinoids (in Cell Modulation) | RARA, RARB, RXRA | RARA 1/4885RARB 2/4885RARG 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.