SCHEMBL7707207

SCHEMBL7707207

Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1SSc1c(C)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GABRP O00591 20/20 0.60
GABRD O14764 20/20 0.60
GABRA1 P14867 20/20 0.60
GABRB1 P18505 20/20 0.60
GABRG2 P18507 20/20 0.60
GABRB3 P28472 20/20 0.60
GABRA5 P31644 20/20 0.60
GABRA3 P34903 20/20 0.60
GABRA2 P47869 20/20 0.60
GABRB2 P47870 20/20 0.60
GABRA4 P48169 20/20 0.60
GABRE P78334 20/20 0.60
GABRA6 Q16445 20/20 0.60
GABRG1 Q8N1C3 20/20 0.60
GABRG3 Q99928 20/20 0.60
GABRQ Q9UN88 20/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7713492 0.90 GABRP (0.66) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL9489922 0.89 GABRP (0.57) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL9248738 0.88 GABRP (0.56) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7707055 0.88 GABRP (0.56) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL6168324 0.88 GABRP (0.56) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL9531132 0.88 GABRP (0.56) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7711342 0.87 GABRB3 (0.58) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7707160 0.86 GABRP (0.58) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7711744 0.85 GABRB3 (0.53) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL10628680 0.83 GABRB3 (0.59) GABRPGABRDGABRA1GABRB1GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6372774-B1 THESE COMPOUNDS POSSESS ARTHROPODICIDAL, PLANT NEMATOCIDAL, ANTHELMINTIC AND ANTI-PROTOZOAL PROPERTIES RHONE-POULENC AGRICULTURE LTD. (GB) 2002-04-16 US disclosed
US-5714191-A PESTICIDES USED IN MEDICATED FEEDSTUFF, MINERAL SALT LICK OR EDIBLE BAIT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-02-03 US disclosed
US-5608077-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS, ANTIPROTOZOA AGENTS RHONE-POULENC AGRICULTURE LTD. (GB) 1997-03-04 US disclosed
US-5547974-A INSECTICIDES, NEMATOCIDES, ANTHELMINTICS RHONE-POULENC AGRICULTURE LTD. (GB) 1996-08-20 US disclosed
EP-0579280-A1 Pesticidal method using N-phenylpyrazoles RHONE-POULENC AGROCHIMIE (FR) 1994-01-19 EP disclosed
US-5232940-A Controlling insects, plant nematodes, helminths, protozoa BASF AGRO B.V., ARNHEM (NL), WADENSWIL-BRANCH (CH) 1993-08-03 US disclosed
EP-0201852-B1 AGENT AGAINST NOXIOUS PLANTS BASED ON PYRAZOL DERIVATIVES BAYER AG (DE) 1990-08-16 EP disclosed
US-4945165-A Insecticide, miticide, nematicide BAYER AKTIENGESELLSCHAFT (DE) 1990-07-31 US disclosed
US-4804675-A 1-aryl-4-alkylthiopyrazol-5-amine derivatives, composition containing them, and method of using them to combat insects, arachnids, and nematodes BAYER AKTIENGESELLSCHAFT (DE) 1989-02-14 US disclosed
EP-0234119-A1 Pesticidal method using N-phenylpyrazoles RHONE-POULENC AGROCHIMIE (FR) 1987-09-02 EP disclosed
WO-1987003781-A1 PESTICIDAL METHOD USING N-PHENYLPYRAZOLES MAY & BAKER LIMITED (GB) 1987-07-02 WO disclosed
EP-0201852-A2 Agent against noxious plants based on pyrazol derivatives BAYER AG (DE) 1986-11-20 EP disclosed